Uses of Pirfenidone

Pirfenidone is used in the treatment of mild to moderate Idiopathic pulmonary fibrosis (tissues in your lungs become swollen and scarred over time, and as a result makes it difficult to breathe deeply) in adults.

Therapeutic Category

Pirfenidone: Anti-fibrotic or Anti-inflammatory agents (Pyridones)

How Pirfenidone works

Pirfenidone works by exhibiting anti-inflammatory, antioxidant and antifibrotic properties that suppress the factors (transforming growth factor -ß (TGF-ß)) causing scarring and swelling of the tissues. As a result, it treats and controls the fibrosis of the tissues resulting in improving lung function and helping in breathing more easily. 

Common side effects of Pirfenidone

• infections of the throat or the airways and sinusitis, influenza and/or common cold
• nausea
• stomach problems such as acid reflux, vomiting, constipation, diarrhoea, indigestion or stomach upset
• weight loss, decreased appetite
• difficulty sleeping
• tiredness, dizziness, headache
• shortness of breath
• cough
• joint pain
• bladder infections
• feeling sleepy
• change in taste sensation
• hot flushes
• bloating, abdominal pain and discomfort, heartburn, and flatulence
• sunburn or skin reactions due to exposure in the sun or to sun lamps
• skin problems such as rashes, itchy skin, redness, dry skin
• muscle pain, weakness or feeling low in energy
• chest pain

When to consult your doctor

Consult your doctor:

• in case of accidental overdosage
• if you experience signs of angioedema or serious allergic reactions or anaphylaxis such as urticaria, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or feeling faint
• if you experience reddish non-elevated, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes. These serious skin rashes can be preceded by fever and flu-like symptoms. (Stevens-Johnson syndrome or toxic epidermal necrolysis)

Health Tips for Pirfenidone

• Take Pirfenidone with food to help improve its absorption and reduce the risk of stomach upset
• Do not drink grapefruit juice as it may effect how this medicine works
• Drink an adequate amount of water throughout the day to maintain proper hydration. This can help prevent or alleviate potential side effects such as nausea or gastrointestinal discomfort
• Pirfenidone may increase your sensitivity to sunlight. To minimize the risk of sunburn or sun damage, limit your sun exposure and use protective measures such as sunscreen, hats, and protective clothing when outdoors
• Maintain a healthy lifestyle along with the medication for overall well-being such a eating a balanced diet, engage in regular physical exercise as recommended by your doctor, get enough rest, and avoid smoking or exposure to second-hand smoke
• Consider joining support groups or seeking emotional support from friends, family or healthcare professionals. They can valuable guidance, understanding, and encouragement